By R. B. Greenblatt (auth.), J. Cortés-Prieto, A. Campos-da-Paz, R. B. Greenblatt (eds.)
Read or Download The Development of a New Triphasic Oral Contraceptive: The Proceedings of a Special Symposium held at the 10th World Congress on Fertility and Sterility, Madrid July 1980 PDF
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Additional resources for The Development of a New Triphasic Oral Contraceptive: The Proceedings of a Special Symposium held at the 10th World Congress on Fertility and Sterility, Madrid July 1980
Ilf[ol. Sail/d. , 54, 45 15. , Schneider, \V. H. F. and Spona, J (1977;. Radioimmunoassay. In E. ). Radioisolope ill Geburtslzilfe lind (~)'I/dko/ngie, p. 373. : Berlin: 'Yalter de Gryuter) 16. , Schneider, \\'. H. F. and Johansson, E. D. B. (1977). Injectable depot contraceptives on n-Xorgestrel basis II. Clinical pharmacokinetic studies \\'ith ll-:'\orgestrel undecylate in women. Conlrt/ceplioll, 15, 413 17. Spona,]. (1974). Rapid assay of LH and evaluation of data by new computer program. In RIA alld Relaied Procedures in lvledicine.
8 -. , Schematic diagram su perimpo sing th e a dminist ra tion of th e oestrogen and levonorgestrel components of the new triphasic contraceptive over a background of normal endogenous hormon e lev els. VE The first phase (early to mid-follicular) - 6 tablets of30 ,ug EE plus 50 pg LNg - provides both low oestrogen and low progestagen. This dosage attempts to mimic follicular secretion necessary for promoting endometrial growth. Ovarian steroidogenesis is not completely arrested as shown by oestradiol levels similar to those found in the follicular phase 24 • In the second phase (peri-ovulatory) increased amounts of EE and LNg are provided in order to inhibit the LH surge and ovulation.
Lowering ofHDL cholesterol by oral contraceptives. Lancet, 2, 269 24. , Harper, R. W. J. (1978). Severity of coronary atherosclerosis related to lipoprotein concentration. Br. Aled. , 2, 3H3 25. Miller, G. L and Miller, N. E. (1975). HDL concentration and development of ischemic heart disease. Lancet, 1, 16 26. Miller, N. , Porde, O. H. and Theile, D. S. (1977). The Thromso heart study: HDL and coronary heart disease: A prospective case control study. Lancet, 1, 965 27. Zador, G. and Nilsson, B.