By J.P. Mohr, MS, MD, Dennis W. Choi, MD, PhD, James C. Grotta, MD, Bryce Weir, OC, MD, FRCSC, FACS, FRCSEd (Hon), and Philip A. Wolf, MD (Eds.)

First released in 1986 below the editorial path of Dr. Henry J.M. Barnett, this encyclopedic, but readable textual content has served as a ''one-stop shop'' for generations of practitioners looking authoritative insurance of the clinical and medical features of stroke. The 4th variation encompasses a new editorial staff led through former co-editor Dr. J.P. Mohr, providing up to date and elevated insurance of epidemiology and prevention, scientific manifestations, analysis, particular scientific illnesses regarding stroke, pathophysiology, and scientific and surgical therapy.

  • Explains the mechanisms of stroke and stroke-related diseases.
  • Provides accomplished scientific guidance-from spotting the scientific manifestations of stroke and utilizing the newest laboratory and imaging experiences to reach at a analysis to clinical and surgery planning.
  • Features a brand new editorial crew led via former co-editor Dr. J.P. Mohr.
  • Devotes a brand new part to Epidemiology and Prevention, with chapters on distribution, probability elements and prevention, and outcomes.
  • Offers clean views from new authors at the most recent advances in imaging, addressing practical neuroimaging, quickly MRI, and more.
  • Includes an improved Pathophysiology part, with new chapters on excitotoxicity, apoptosis, irritation, intracellular signaling, restoration of functionality, and more.
  • Contains a reorganized and multiplied treatment part, with separate subsections on clinical remedies (including new anticoagulants and neuroprotection brokers) and surgical remedies (including new strategies for prevention and service of stroke damage).

With over a hundred thirty extra participants

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Additional resources for Stroke. Pathophysiology, Diagnosis, and Management

Example text

The studies that distinguished between migraine with and migraine without aura usually detected a higher risk for migraine with aura. The contribution of migraine to stroke risk drops with increasing age. The WHO study and other case-control studies found an increase in stroke risk in women younger than 45 years who smoked and in those who used oral contraceptives. Unruptured Intracranial Aneurysms Detection of an unruptured intracranial aneurysm (UIA) presents a therapeutic dilemma in which risk of future rupture must be weighed against the risks of intervention.

This finding suggests a high toll for surgery in these subjects, who were for the most part neurologically normal before surgery. Clearly, further study is needed, particularly with the availability and increasing utility of neurovascular interventions that promise lower rates of death and disability. 74,75A similar relationship between cigarette smoking and stroke was found in Hawaiian Japanese men after 10 years of follow-up in the Honolulu Heart Study, in which cigarette smoking made a significant independent contribution to cerebral infarction and risk of intracranial h e m ~ r r h a g e .

6% had none of these diseases. Cardiac disease is an important precursor of stroke; this subject is also discussed in detail in several other chapters. Coronary Heart Disease In the Framingham study, CHD was ascertained prospectively on biennial examination as well as through monitoring of hospitalizations. CHD predisposes to stroke by a variety of mechanisms-as a source for embolism from the heart; by virtue of shared risk factors; as an untoward effect of m e d d and surgical treatments for coronary atherosclerotic disease; and less commonly, as a consequence of pump failure.

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