By Isabel Stabile, J. G. Grudzinskas, T. Chard (auth.), Isabel Stabile PhD, MRCOG, J. G. Grudzinskas MD, FRCOG, FRACOG, T. Chard MD, FRCOG (eds.)

Sixteen British experts pool their huge wisdom of spontaneous abortion in a single resource. Their dialogue is without delay appropriate to scientific events and is helping determine parts of discussion and replacement methods.

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Extra resources for Spontaneous Abortion: Diagnosis and Treatment

Sample text

Curettage accounts for most cases, with adhesions most likely to develop when the procedure is performed 3 or 4 weeks postpartum. Affected individuals are usually suspected because of menstrual abnormalities, but 15 %-30% of cases become manifested following repeated abortions. If adhesions are detected in a woman experiencing repetitive losses, lysis of the adhesions under direct hysteroscopic visualisation should be performed. Approximately 50% of subjects conceive after surgery, but the frequency of abortions remains high.

1988) Fetal death and work in pregnancy. Br J Ind Med 45:148-157 Narod SA, Khazen R (1989) Spontaneous abortions in Ontario, 1979 to 1984. Can J Public Health 80:209-213 Royal College of General Practitioners' Oral Contraception Study (1976) The outcome of pregnancy in former oral contraceptive users. Br J Obstet Gynaecol 83:621-627 Silman AJ, Black C (1988) Increased incidence of spontaneous abortion and infertility in women with scleroderma before disease onset: a controlled study. Ann Rheum Dis 47:441-444 Stein Z, Kline J, Susser E, Shrout P, Warburton D, Susser M (1980) Maternal age and spontaneous abortions.

1986; Faulk et al. 1989) between mother and father would be deleterious because fetus and mother would be less likely to differ antigenically. Direct experimental support for a beneficial effect of maternal-fetal incompatibility includes: (1) increased placental size in mouse fetuses that result from matings in which paternally derived histocompatibility antigens differ from maternal antigens; (2) higher implantation frequencies in histoincompatible murine zygotes; and (3) maintenance of genetic polymorphisms at major histocompatibility loci despite over 70 generations of brother-sister matings in rats (Beer and Billingham 1976).

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