By Thomas F. DeLaney MD, Hanne M. Kooy MD

This quantity is the 1st complete and sensible scientific reference on proton and charged particle radiotherapy. the 1st half the booklet explains the therapy supply platforms used, bargains specified counsel on remedy making plans thoughts, examines key scientific matters in proton radiotherapy, and experiences contemporary event with heavier charged particle radiotherapy. the second one 1/2 the e-book bargains "how-to" details on remedy of pediatric tumors, lymphomas, and tumors of the valuable anxious approach, eye, cranium base, cervical backbone, bone and smooth tissue, paranasal sinus, nasal hollow space, nasopharynx, oropharynx, oral hollow space, salivary glands, prostate, lung, gastrointestinal tract, lady reproductive tract, and breast. greater than a hundred full-color illustrations supplement the textual content.

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I. New York: Plenum Publishing; 1982:195-293. 63. Chu WT, Ludewigt BA, Renner TR. Instrumentation for treatment of cancer using proton and light-ion beams. Rev Sci Instrum. 1993;64:2055-2122. 64. Slater JM, Archambeau JO, Miller DW, et al. The Proton Treatment Center at Loma Linda University Medical Center: Rationale for and description of its development. Int J Radiat Oncol Biol Phys. 1992;22:383-389. ; Kooy, Hanne M. 30 31 Title: Proton and Charged Particle Radiotherapy, 1st Edition Copyright ©2008 Lippincott Williams & Wilkins 2 Radiobiology of Charged Particles Leo Gerweck Harald Paganetti ENERGY DEPOSITION AND RELATIVE BIOLOGICAL EFFECTIVENESS The number of ionized biomolecules produced per unit dose of protons, heavier charged particles and x-rays is similar, but the resulting biological effects substantially differ.

Int J Radiat Oncol Biol Phys. 2000;47:1051-1058. 24. Gueulette J, Octave-Prignot M, De Costera BM, et al. Intestinal crypt regeneration in mice: A biological system for quality assurance in non-conventional radiation therapy. Radiother Oncol. 2004;73(Suppl 2):S148-S154. 25. Robertson JB, Williams JR, Schmidt RA, et al. Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells. Cancer. 1975;35:1664-1677. 26. Gerweck LE, Zaidi ST, Zietman A. Multivariate determinants of radiocurability I: Prediction of single fraction tumor control doses.

Biological imaging of heavy charged-particle tracks. Radiat Res. 2003;159:676-684. 2. Nikjoo H, Uehara S, Wilson WE, et al. Track structure in radiation biology: Theory and application. Int J Radiat Biol. 1998;73:355-354. 3. Goodhead DT. Radiation effects in living cells. Can J Phys. 1989;68:872-886. 4. Kawata T, Ito H, Wu H, et al. Chromosome aberrations induced by high-LET radiations. Biol Sci Space. 2004;18:216-223. 5. Ryberg B. Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments.

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