By John G. Scandalios (Eds.)

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If changes in mRNA activity do occur, this could be a consequence of a change in the number of mRNA molecules present, resulting from some alteration in the genetic control of mRNA production and degradation. Alternatively, it could result from a develop­ mental change in the structure of the mRNA, bringing with it an altered efficiency of mRNA translation. A decision between these last two possi­ bilities would have many implications regarding the basic molecular de­ tails of temporal gene regulation.

A and late in strain A. By, which has the phenotype H-2b-early. In this cross the developmental phenotype was determined by a single Mendelian factor that proved to be closely linked to H-2 (0/165 recombinants). The new locus, called Intrinsic (Int) acts eis in hétérozygotes, which express their erythrocyte B antigen at birth and their A antigen only sev­ eral days later. This eis expression confirms that H-2 developmental regu­ lation is specific to this gene product and is not a general reflection of erythrocyte development.

4. Drosophila Enzymes King (1969) has described a genetically determined developmental dif­ ference in xanthine dehydrogenase levels in Drosophila. In several strains of flies enzyme levels increase steadily in the days following emergence of adult flies at eclosion. However, unlike other strains the Sy strain only maintains this increase until the second day, at which time it begins a sharp decline in activity. Unfortunately, the genetic basis for this obser­ vation has not been determined. , 1976).

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