By P. Wyss, Y. Tadir, B.J. Tromberg, U. Haller
The photodynamic approach contains the management of a photosensitizer by way of program of laser mild. while gentle interacts intracellularly with the photosensitizer, the photon power absorbed by means of the sensitizing molecule quite often generates photooxidation for tissue destruction or fluorescence for diagnostics. Photomedical options supply a minimally invasive, ambulatory process in gynecology, now not wanting anesthetics. A historical past of photomedicine explains the most components and mechanisms of photomedical recommendations. one of many major chapters is devoted to the biochemical and biophysical features of photomedicine reminiscent of characterization of photosensitizers, their interplay with mild, their destruction, the optical dosimetry and optical houses of tissues. The medical a part of this e-book summarizes the cutting-edge job in all significant gynecologic functions, from cervix to breast, and gives the reader with an knowing of photodynamic treatment and easy mechanisms. Photon-assisted replica, e.g. laser-assisted fertilization, embryo hatching and prenatal analysis, makes up the ultimate chapters. Belonging in each clinic or college library, this booklet underscores why photomedicine appeals to any such vast spectrum of scholars, easy scientists, clinicians, and participants of the company global.
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Additional resources for Photomedicine in Gynecology & Reproduction
Photochem Photobiol 1996;64:174–181. Jori G: Tumour photosensitizers: Approaches to enhance the selectivity and efficiency of photodynamic therapy. J Photochem Photobiol B 1996;36:87–93. Winkelman JW, Kimel S: The relationship between porphyrin transport and tissue uptake with photosensitization from 1O2; in Kessel D (ed): Photodynamic Therapy of Neoplastic Disease. Boca Raton, CRC Press, 1990, vol 2, pp 29–42. Boyle RW, Dolphin D: Structure and biodistribution relationships of photodynamic sensitizers.
In contrast to AlPcS4, the fluorescence of ZnPc decreased exponentially during irradiation, no fluorescence increase could be observed. A nonlinear Ca2+ increase, as in the case of AlPcS4, could not be detected. This is demonstrated in figure 5. Morphological changes in the cells during the ‘bleaching’ process were significant. This correlates with the fact that ZnPc was a very efficient photosensitizer and induced no stimulation of cell proliferation at low light doses . The failing of the nuclear Ca2+ increase in a nonlinear way seems to be the key for the different behavior.
Our results confirm reports in the literature that tumor control by PDT with liposomal ZnPc requires vascular damage, the endothelium is probably a target as well as the tumor cells . These two examples demonstrate in which way primary and secondary phototoxicity of hydrophilic and lipophilic photosensitizers can be modulated. An accumulation in the endothelial cells as well as tumor cells as observed for ZnPc explains the observed secondary and primary phototoxic effects. In the case of AlPcS4 however, direct tumor cell killing mechanisms are probably more important and should therefore be optimized.