By P. Wyss, Y. Tadir, B.J. Tromberg, U. Haller

The photodynamic approach contains the management of a photosensitizer by way of program of laser mild. while gentle interacts intracellularly with the photosensitizer, the photon power absorbed by means of the sensitizing molecule quite often generates photooxidation for tissue destruction or fluorescence for diagnostics. Photomedical options supply a minimally invasive, ambulatory process in gynecology, now not wanting anesthetics. A historical past of photomedicine explains the most components and mechanisms of photomedical recommendations. one of many major chapters is devoted to the biochemical and biophysical features of photomedicine reminiscent of characterization of photosensitizers, their interplay with mild, their destruction, the optical dosimetry and optical houses of tissues. The medical a part of this e-book summarizes the cutting-edge job in all significant gynecologic functions, from cervix to breast, and gives the reader with an knowing of photodynamic treatment and easy mechanisms. Photon-assisted replica, e.g. laser-assisted fertilization, embryo hatching and prenatal analysis, makes up the ultimate chapters. Belonging in each clinic or college library, this booklet underscores why photomedicine appeals to any such vast spectrum of scholars, easy scientists, clinicians, and participants of the company global.

Show description

Read Online or Download Photomedicine in Gynecology & Reproduction PDF

Best obstetrics & gynecology books

National Medical Series: Obstetrics and Gynecology

A student-favorite overview of the OB/GYN clerkship and training for the shelf examination now bargains a CD-ROM that comes with the entire book's questions in an interactive, digital layout; present cures and methods; a wealth of extra figures, tables, and inquiries to support scholars larger assimilate details; revised inquiries to extra heavily fit USMLE guidance; up to date case reports for convinced scientific determination making; and a brand-new bankruptcy on breast problems.

Health Promotion in Midwifery 2nd Edition: Principles and practice

Well-being advertising in Midwifery explores the foundations of healthiness merchandising in the sensible context of midwifery. It basically outlines and discusses the midwife’s function in well-being advertising, making it crucial interpreting for all pupil and working towards midwives, in addition to scientific practitioners. Emphasizing the hyperlink among conception and perform, the second one variation comprises chapters on family violence, sexual future health, breastfeeding, and psychological overall healthiness promoting.

Women's Sexual Function and Dysfunction: Study, Diagnosis and Treatment

The 1st, definitive textual content on girl sexual disorder, this significant new ebook summarizes the present physique of information within the box, lines the background of advancements within the sector, and identifies paintings nonetheless wanted sooner or later. Reflecting a multidisciplinary method of the topic, the ebook information the equipment and fabrics for making sure the ideal administration of girls with sexual illnesses, and concentrates at the presentation of evidence-based facts about the body structure, pathophysiology, analysis and therapy of sexual functionality and disorder in girls.

Protocols for high-risk pregnancies : an evidence-based approach

High-risk pregnancies current life-threatening demanding situations to 2 of your sufferers: the mum and her fetus. The direct, exemplary tips in Protocols for High-Risk being pregnant allows you to -better comprehend your sufferers' stipulations -devise optimal administration options -maximize the end result and reduce the problems for either the mum and her fetus to reinforce medical relevance, every one protocol is written as though the sufferer have been current.

Additional resources for Photomedicine in Gynecology & Reproduction

Example text

Photochem Photobiol 1996;64:174–181. Jori G: Tumour photosensitizers: Approaches to enhance the selectivity and efficiency of photodynamic therapy. J Photochem Photobiol B 1996;36:87–93. Winkelman JW, Kimel S: The relationship between porphyrin transport and tissue uptake with photosensitization from 1O2; in Kessel D (ed): Photodynamic Therapy of Neoplastic Disease. Boca Raton, CRC Press, 1990, vol 2, pp 29–42. Boyle RW, Dolphin D: Structure and biodistribution relationships of photodynamic sensitizers.

In contrast to AlPcS4, the fluorescence of ZnPc decreased exponentially during irradiation, no fluorescence increase could be observed. A nonlinear Ca2+ increase, as in the case of AlPcS4, could not be detected. This is demonstrated in figure 5. Morphological changes in the cells during the ‘bleaching’ process were significant. This correlates with the fact that ZnPc was a very efficient photosensitizer and induced no stimulation of cell proliferation at low light doses [26]. The failing of the nuclear Ca2+ increase in a nonlinear way seems to be the key for the different behavior.

Our results confirm reports in the literature that tumor control by PDT with liposomal ZnPc requires vascular damage, the endothelium is probably a target as well as the tumor cells [25]. These two examples demonstrate in which way primary and secondary phototoxicity of hydrophilic and lipophilic photosensitizers can be modulated. An accumulation in the endothelial cells as well as tumor cells as observed for ZnPc explains the observed secondary and primary phototoxic effects. In the case of AlPcS4 however, direct tumor cell killing mechanisms are probably more important and should therefore be optimized.

Download PDF sample

Rated 4.77 of 5 – based on 16 votes