By Milo Gibaldi, Donald Perrier

Show description

Read or Download Pharmacokinetics, Second Edition (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) PDF

Best textbooks books

Digital Logic Techniques: Principles and Practice

1 Numerical illustration of data. - 2 Operations on binary information. - three Combinational common sense layout. - four Sequential common sense basics. - five layout of sequential common sense circuits. - 6 The electronic approach. - 7 sensible electronic circuits. - solutions to difficulties.

Learning and Literacy over Time: Longitudinal Perspectives

Studying and Literacy over the years addresses gaps in literacy research—studies supplying longitudinal views on newbies and the trajectory in their studying lives in and out of faculty, and reports revealing how earlier reviews with literacy and studying tell destiny studies and practices.

Additional info for Pharmacokinetics, Second Edition (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)

Example text

Data from Ref. 3. SUbject 2663, dose = 10 mg{kg. ) The zero-time intercept obtained by extrapolation of the terminal linear phase to t = 0 is An' Successive application of the method of residuals (Appendix C) will yield linear segment(s) with slope(s) and intercept(s) from which the remaining value(s) of A and A can be determined. The constants A R. and AR. may be obtained graphically as shown in Fig. 4 or with the aid of a digital computer. The best approach is to fit the entire plasma concentration-time curve by means of a digital computer program which provides a nonlinear regression analysis of the curve (Appendix H).

106) For a given drug, as the absorption rate constant increases, the time required for the maximum plasma concentration to be reached decreases. The maximum plasma concentration is described by SUbstituting tmax for t in Eq , (1. 94) : C -Kt -k t k FX a O (max _ e a max) max = V(k - K) e a (1. 107) However, a simpler expression can be obtained. 108) a Substituting for e -k a t max, according to (1. 108). in (1. 110) Y The values of C ma x and t max under the special circumstance when k a = K is of mathematical interest and will be considered briefly.

Arch. Int. Pharmacodyn. 156:380 (1965) . 3. A. Goldstein. Biostatistics-An Introductory Text. Macmillan, New York, 1964. 4. G. R. Wilkinson and A. H. Beckett. Absorption, metabolism and excretion of the ephedrines in man: I. The influence of urinary pH and urine volume output. J. Pharmacol. Exp. Ther. 162:139 (1968) . 5. J. A. Taylor. Pharmacokinetics and biotransformation of chlorpropamide in man. Glin. Pharmacol. Ther. 13: 710 (1972). 6. W. H. Barr, L. M. Gerbracht, K. Letcher, M. Plaut, and N.

Download PDF sample

Rated 4.67 of 5 – based on 11 votes