By M. Frier, A C Perkins

This article defines the position and scope of nuclear drugs imaging concepts (gamma scintigraphy) in pharmaceutical examine, giving details from medical trial information.

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Nuclear Medicine in Pharmaceutical Research (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES)

This article defines the position and scope of nuclear drugs imaging suggestions (gamma scintigraphy) in pharmaceutical learn, giving details from scientific trial information.

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Extra info for Nuclear Medicine in Pharmaceutical Research (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES)

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2. The gamma camera comprises one or more large detector heads shielded in lead to reduce the ingress of background radiation. 3). On the face of the head is a removable lead plate called the collimator. This has a series of fine holes to channel the gamma photons onto the detector crystal. Any gamma ray not passing parallel with the holes is absorbed by the surrounding lead septa. Different types of collimator with varying thicknesses of lead septa between the holes are used for imaging radionuclides, producing different energies of gamma rays.

Providing there has been no movement of the subject, the count rate obtained from the ROI in each frame of the series can be used as a data point on the activity time curve. This technique can be used to measure rates of uptake, dissolution, spread and relative function. Once the curves have been generated a number of parameters may be measured, for example gradients and areas under the curve. 10 Quality Assurance Good clinical practice demands that the equipment is maintained in optimum working order.

A range of factors can be pre-set to include a setting specific for each radionuclide. Providing the instrument is calibrated for the appropriate radionuclide and the volume of the sample is known, the specific activity can be 1 2 Where 1 Bq = the disintegration of one atom per second. 1 Schematic diagram of a radionuclide dose calibrator calculated to give the activity per millilitre of the sample (MBq/ml). Alternatively, if the weight of the sample is known, the specific activity may be expressed as MBq/mg.

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