By P. J. Vatikiotis

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A gene mutation or point mutant in s uch experiments means, of course, a mutant which with the best available methods does not show a cytological rearrangement. But not all mutants can be checked cytologically. In the salivary chromosomes some regions are more favorable than others . In favorable regions a deficiency , down to a s ingle band, can be checked easily ; in others it is more difficult. Small inversions are even more difficult. Inversions of a few bands may or may not be detected without a very detailed study , wh ich usually cannot be made in connection with large - scale quantitative work.

9. A diagrammatic representation of a chiasma as described by Janssens. The Genes are Arranged in Linear Order on the Chromosomes (Sturtevant , 1913) In 1913, A. H. Sturtevant showed that genetical analysis of DrosojJhila hybrids could show not only that crossing-over occurred but that the invisible genes are arranged on the chromosome in a linear array corresponding to the linear order of the visible "beads" seen by the cytologist. Sturtevant arrived at his theory of the linear order of the genes by studying the progeny of a female which was hybrid for three different defects.

E. , were considered important; the same catholicity prevailed generally in the third generation. The present fourth generation has been overwhelmed by the mass of precisely-detailed and revolutionary discoveries of biochemistry, and has been completely unable to consider the biological problem in its broadest aspects hence, an operational, almost purely pragmatic, point of view prevails among the current geneticists. " Morgan, Bateson, Belling and Darlington continued 32 COLD WAR IN BIOLOGY in Mendel's foot steps with the concept of a discrete particulate gene, but this view has been rejected This chapter will attempt to present the views of the different theorists and the steady evolution from a conceptual to an operational attitude toward the gene .

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