By Christopher Sutton, G. David Adamson, Kevin D. Jones

Endometriosis - a situation within which the liner of the uterus grows in different belly destinations - is among the most typical explanations of serious interval ache, pelvic discomfort, and irregular bleeding in girls. Untreated, it could actually lead to long term issues resembling pelvic adhesions, ovarian cysts and infertility. now and then, bowel, bladder, and ureters can also be broken. even though clinical thoughts can be found for a few ladies, laparoscopy is often had to make sure the analysis and sometimes surgical intervention -- by means of elimination the endometriotic implants, ovarian cysts and repairing tubal harm -- frequently produces quick ends up in phrases of discomfort aid and greater fertility. This significant new publication, written by means of an the world over well-known crew of specialists, covers the whole diversity of surgical interventions for diagnosing and treating endometriosis.

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Vigano P, Gaffuri B, Somigliana E, et al. Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. stromal cells in culture. Mol Hum Reprod 1998; 4(12): 1150–1156. Garcia-Velasco JA, Arici A, Zreik T, et al. Macrophage derived growth factors modulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Mol Hum Reprod 1999; 5(7): 642–650.

Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms in endometriosis. Mol Hum Reprod 2003; 9(1): 47–52. 28. Osteen KG, Keller NR, Feltus FA, et al. Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium. Gynecol Obstet Invest 1999; 48 (Suppl 1): 2–13. 29. Kokorine I, Nisolle M, Donnez J, et al. Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions. Fertil Steril 1997; 68(2): 246–251.

25,26 Attachment of endometrial tissue and cell viability have been detected as early as 1 day after subcutaneous transplantation of proliferative or secretory human endometrium. 28 The high vascular endothelial growth factor (VEGF) score observed in stromal cells suggests that an active vascular network is a necessary condition for the survival of the graft. 4). 30 Alternatively, the contribution of stromal cells to epithelial cell adhesion could be the secretion of extracellular matrix (ECM) components, or the release of proteases leading to ECM remodeling and formation of an appropriate microenvironment for epithelial cell implantation, proliferation, and organization into endometrial glands.

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