By Michael A. Blake, Mannudeep K. Kalra

This pertinently illustrated and good referenced textual content serves as an updated, beautiful publication of oncologic imaging for radiologists, oncologists, radiation therapists and others concerned with oncologic care. This quantity, with bankruptcy contributions from world-renowned specialists, presents medical and learn info that underpins exact interpretation and good use of melanoma imaging. The e-book additionally highlights new advancements and advances in oncologic imaging.

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Mol Imaging Biol 2004; 6:139-148. 168. Doubrovin M, Ponomarev V, Beresten T, et al. Imaging transcriptional regulation of p53dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci U S A 2001; 98:9300-9305. 169. Serganova I, Doubrovin M, Vider J, et al. Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res 2004; 64:6101-6108. 170. Uhrbom L, Nerio E, Holland EC. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.

It has been shown that in high-grade gliomas, tumor cells infiltrate along vascular channels but do not destroy the preexisting cytoarchitecture [17]. Vasogenic edema associated with metastases is also a passive process that does not necessarily destroy the underlying structure or neuronal tissue [125]. 6 Multiparametric Analysis Histologically, gliomas often demonstrate considerable heterogeneity, with focal areas of malignant features dispersed over several regions. Due to this inherent heterogeneity, MRI techniques such as PWI, DWI and 1H MRS, when used independently, often lead to ambiguous results in grading of gliomas, specifically oligodendrogliomas [7, 106, 122-124].

Ross B, Michaelis T. Clinical applications of magnetic resonance spectroscopy. Magn Reson Q 1994; 10:191-247. 98. Howe FA, Barton SJ, Cudlip SA, et al. Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy. Magn Reson Med 2003; 49:223-232. 99. Shimizu H, Kumabe T, Shirane R, Yoshimoto T. Correlation between choline level measured by proton MR spectroscopy and Ki-67 labeling index in gliomas. AJNR Am J Neuroradiol 2000; 21:659-665. 100. Shino A, Nakasu S, Matsuda M, Handa J, Morikawa S, Inubushi T.

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