By John M. Mathis

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Useful matching tools include tools to crop mobile anatomy, perform interactive pre-matching. Good evaluation tools are ‘sliding window’ and overlay views in Table 1. Overview of the classes of registration algorithms used in radiotherapy. Each of these algorithms is suitable for specific types of applications. A comprehensive system should therefore provide multiple of these algorithms • RT Dose, containing dose data generated by a treatment planning system in one or more of several formats: three-dimensional dose data, isodose curves, DVHs, or dose points.

31Σ 2. 50Σ 2. 79Σ Dose level 85% 90% 95% Margin 0. 5σ 0. 6σ 0. 7σ 27 28 I. Foundations Towards a better definition of the target, many studies are looking at combining information from multiple modalities. However, none of these provide a true ‘golden standard’ of the tumor extent. Possibly, the solution lies in the inclusion of pathology information into those studies. Furthermore, the inclusion of functional information in treatment planning may provide important information in relation to normal tissue complications.

Even the modifications of the original concept often referred to as ‘biological optimization’, described below, basically keep the same logical structure of the optimization while only the mathematical formulation of the objectives of the optimization is modified. One common factor of both approaches is the selection of the energy fluence profiles for a pre-selected set of beam ports as the only treatment parameters to be optimized in the planning process. We consider the respective physical optimization as the current ‘standard model’ of IMRT optimization and review some of its detailed features later.

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