By Lawrence J., M.D. Albers, Rhoda Hahn, Christopher, M.D. Reist

This compact guide beneficial properties dosage, part influence, and drug interplay info for all psychiatric medications. It comprises info that's worthy to the psychiatrist, internist, and pupil.

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Extra resources for Handbook of Psychiatric Drugs, 2004 Edition (Current Clinical Strategies)

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Lithium-induced diabetes insipidus may be treated with the diuretic amiloride (5-10 mg/day). Renal function should be monitored. C. Thyroid: Hypothyroidism may occur, and it may be treated with levothyroxine. Monitor TSH several times per year. D. Cardiovascular: Cardiovascular side effects include T-wave flattening or inversion and, rarely, arrhythmias which usually require discontinuation. Edema may respond to spironolactone 50 mg/day, or a reduction of the lithium dose. E. Dermatological: Side effects include rash and acne.

These include a basic chemistry panel, thyroid function tests, CBC, and an EKG in patients who are over 40 years old or with pre-existing cardiac disease. In females of childbearing age, pregnancy should be excluded. IV. Dosage and Administration A. Lithium is given in divided doses. Bid dosing with a slow-release formula is recommended. The starting dose for most adults is 300 mg bid-tid. The average dose rage is 900-2100 mg/day. B. Single daily dosing can be used if the daily dose is less than 1200 mg/day.

The average daily dose is between 900 and 1800 mg/day, but doses up to 2400 have been used. 2. Monitoring of serum levels is not necessary. There is no information available regarding a therapeutic window. 3. Significantly lower doses should be given to patients with impaired renal function or reduced creatinine clearance. C. Therapeutic Response: 2-4 weeks D. Pregnancy and Lactation: Pregnancy category C. There are no controlled studies in pregnant women. Gabapentin should be avoided during the first trimester.

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