By Emil Skamene

Genetic keep watch over of usual Resistance to an infection and Malignancy.

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However/ the rate of infection in A/J mice was increased (from 53 to 100%) but that of BALB/c was reduced (from 100 to 8 3 % ) . Murine Visceral Leishmaniasis 33 Table 2. Effect of Levamisole (25 mg/kg monthly) on the rate of infection in A/J and BALB/c mice Days a f t e r BALB/c A/J i n f e c t i o n Treated Control Treated Cont rol 20 5 5 20 40 5 36 62 32 90 60 5 47 80 100 80 10 57 yo 100 125 20 78 100 100 1()7 31 78 100 100 Mice received the first injection of Lev. (IP) at the time of infection.

Mexicana L. tropica L. tropica L. donovani L. donovani (chronic) G Howard, Hale and Chan-Liew, personal communication Behlin, Mauel and Sordat (57) Perez, Labrador and Torrealba (58) Nasseri and Modabber (56) Preston, Bebehani and Dumonde (55) Bradley (45) Blackwell, Freeman and Bradley (51) Genetic Resistance to Protozoa 23 It is clear that the detailed analysis of particular parasite systems is now proving very fruitful and that close interaction between studies of the genetics and the mechanisms of resistance is specially important, while it is necessary for those wishing to understand acquired resistance to do so in strains controlled for innate resistance if confusion is not to result.

E. BALB/c) to both parasites. These mice do not give a spectral disease with different doses of organisms. e. C57BL/6) which lack Lsh r gene but are relatively resistant (7,8), however, can give rise to nonhealing lesions in some of the animals with higher doses (2). In these animals another set of genes responsible for acquired immune responses regulate the form of infection. At low parasite load they recover and at high doses they are unable to control the infection. tropica (12) supports this notion.

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