By William J. Stone

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When this occurs there is failure to excrete adequate amounts of water in the urine and, hence, a total body excess of water 1. Renal Physiology and Pathophysiology 25 develops with attendant hyponatremia and hypoosmolality. This is the socalled syndrome of inappropriate secretion of antidiuretic hormone (93, 94). H. Other Hormones In addition of the aforementioned hormones other hormones may have effects on the kidneys. , thyrocalcitonin. , "natriuretic hormones," little is known about their physical properties, sites of produc­ tion, and site or mechanism of action in the kidney.

Van Ypersele de Strihou, C. Potassium homeostasis in renal failure. Kidney Int. 11, 491 — 504 (1977). Schon, D. , and Hayslett, J. P. Mechanism of potassium excretion in renal insufficiency. Am. J. Physiol. 227, 1323-1330 (1974). , Schultze, R. , and Trizna, W. Functional profile of the isolated uremie nephron. Potassium adaptation in the rabbit cortical collecting tubule. J. Clin. Invest. 64, 1033-1043 (1979). Hays, C. , McLeod, M. , Robinson, R. , and Stead, E. A. An extrarenai mechanism for the maintenance of potassium balance in severe chronic renal failure.

C , Arnaud, C. , and Schrier, R. , 1,25-dihydroxycholecalciferol effects in chronic dialysis: A double-blind controlled study. Ann. Intern. Med. 88, 774-780 (1978). 54. Massry, S. , Arieff, A. , Coburn, J. , Norman, A. , and Friedler, R. M. Skeletal resistance to the calcémie action of parathyroid hormone in uremia: Role of 1,25 (OH) 2 D 3 . Kidney Int. and 9, 467-474 (1976). 55. Massry, S. , Coburn, J. , Lee, D. N. , and Kleeman, C. R. Skeletal resistance to parathyroid hormone in renal failure.

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