By Karen Hassey Dow

Collage of relevant Florida, Orlando.Text on breast melanoma for nurses and overall healthiness care execs. Discusses clinical administration, nursing aid, and relatives matters pertaining to breast melanoma. 26 U.S. participants.

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Extra resources for Contemporary Issues in Breast Cancer (Jones and Bartlett Series in Oncology)

Example text

Genetic testing for cancer does not provide definitive information about whether an individual will ever be diagnosed with cancer, the age at which a cancer will be diagnosed, or even (in some cases) the type of cancer that might develop (Kelly, 1994). , 1993). Tests for predisposition to common disorders will be of great commercial interest. They could have substantial potential for harm to individuals and families in terms of insurability and employability, as well as substantial benefit from the potential of early preventive and therapeutic interventions (Institute of Medicine, 1994).

It is predicted that by the year 2005, every one of the estimated 100,000 human genes will have been identified (Nowak, 1994). When that work has been completed, it is generally assumed that it will be possible to characterize and understand the genes and their organization in the genome. This will have an enormous impact on the understanding of physiological processes in humans, in both healthy and disease states, and consequently on the practice of health care in general. Each of the numbered structures in Figure 1-1 is a pair of chromosomes.

Mismatched nucleotides signal a genetic error. In their normal roles, DNA mismatch repair genes, like genetic proofreaders, seem able to spot mismatches and orchestrate the necessary repairs (Cleaver, 1994). If these repair genes don't work, errors accumulate in the course of many generations of cell division and eventually a cancerous mutation occurs. These genes have been described as being like the spell-check in a word processing computer program (Service, 1994). One gene, hMSH2, is said to be primarily a replication editor and the other gene, hMLH1, a recombination editor (Radman & Wagner, 1993).

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