By H. Van den Bossche

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Extra resources for Comparative Biochemistry of Parasites

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The situation is much simpler t o determine the requirements of those parasites which are obligate aerobes. Even in this case, however, relatively few parasitic helminths have been proven t o be aerobic in the a d u l t stage, although evidence has been presented t h a t a number of nematode larvae (6) ( 7) ( 8) are aerobic, such as the E u s t r o n g y l e , A s c a r i s and T r i c h i n e l l a larvae. ( 9) The findings of B u e d i n g have established t h a t the a d u l t filarial w o r m , Litomosoides carinii is highly dependent upon oxygen f o r m o t i l i t y and 34 C O M P A R A T I V E B I O C H E M I S T R Y OF P A R A S I T E S survival.

Unlike antimonials, and like p-rosaniline, the antischistosomal drug niridazole has relatively slow onset of a c t i o n ; a hepatic shift of the w o r m s is observed o n l y 2 t o 3 days after a chemotherapeutically effective dosage schedule of niridazole has been i n i t i a t e d . If biochemical 27 ERNEST BUEDING changes in the w o r m s brought about by niridazole are t o be related t o the mode of action of this drug, t h e y should precede the f u n c t i o n a l damage reflected in the loss of a t t a c h m e n t o f the w o r m s t o t h e mesenteric veins of the host.

I n : Oppenheimer, C. ): Handbuch der Biochemie des Menschen und der Tiere 4, Part 2: 446 - 528. W E I N L A N D , E. 1913. Uber einige Aufgaben und Fragen der vergleichenden Physiologie. Sitzungsber. -Med. Sozietät Erlangen 45, 137 - 153. W E I N L A N D , E. 1925. Uber den Gehalt an einigen Stoffen beim Igel im Winterschlaf. Biochem. Z. 160, 66 - 74. W E I N L A N D , E. and von B R A N D , T. 1926. Beobachtungen an Fasciola 22 hepatica C O M P A R A T I V E B I O C H E M I S T R Y OF P A R A S I T E S (Stoffwechsel und Lebensweise).

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