By James R. Jeter Jr.

A chain of monographs. law of the mobile cycle is a posh interplay among the nuclear genome, cytoplasmic swimming pools, organelles, mobilephone floor, and the extracellular atmosphere. How those numerous devices engage to manipulate the telephone cycle is the subject of this ebook

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Honda, Β. , Baillie, D. , and Candido, E. P. ,7. Biol. Chem. 2 5 0 , 6443 (1975). 66. , and Zachau, H. , Nucleic Acids Res. 3 , 3213 (1976). 67. Hyde, J. , and Walker, I. , FEBS Lett. 5 0 , 150 (1975). 68. Hyde, J. , and Walker, I. , Nucleic Acids Res. 2 , 405 (1975). 68a. ,7. Biochem. {Tokyo) 7 2 , 357 (1972). 69. , FEBS Lett. 6 2 , 251 (1976). 69a. Johns, E. , Biochem. J. I l l , 371 (1969). 69b. Johns, E. , Nature (London) 2 2 6 , 650 (1970). 70. Johnson, Ε. , and Allfrey, V. G. Arch. Biochem.

R. Gurley et al. heparin, a different type of probe that interacts primarily with the histone component of chromatin (39, 40, 44) instead of with the D N A component. The results of these experiments are summarized in Fig. 4. When haparin is added to nuclei, this polyanion interacts with histones, causing D N A to be released into the suspending solution (38-40). If the cells used have been grown in the presence of C-thymidine, the released D N A can be measured easily by radioassay (38). Such measurements were made on nuclei isolated from C H O cells traversing G and S phase following synchronization in G arrest by isoleucine deprivation (Fig.

185, 166 (1971). 80. Levina, E. , and Mirzabekov, A. , Dokl. Akad. Nauk SSSR 2 2 1 , 1222 (1975). 81. Li, H. , Nucleic Acids Res. 2 , 1275 (1975). 82. Li, H. , and Weiskopf, Μ. , Biopolymers 14, 211 (1975). 83. Li, H. , and Flemly, D. , Anal. Biochem. 5 2 , 300 (1973). 84. Libby, P. , Biochem. Biophys. Res. Commun. 3 1 , 59 (1968). 85. Libby, P. , Biochem. J. 134, 907 (1973). 2. Chromatin Structure and Postsynthetic Modifications 33 86. Lilley, D. M. , Proc. Con]. Mol. Spectrosc, 6th, (1977). 87.

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