By Jair C. Soares

Reviewing discoveries in anatomical, useful, and neurochemical in vivo and pharmacological stories, this quantity consolidates fabric on chemical imaging with SPECT and puppy radiotracer reviews, and magnetic resonance spectroscopy (MRS) perspectives of the human mind. Edited via best mind imaging researchers within the box, with contributions from thirty-four experts, the booklet offers info on structural, practical, and neurotransmitter abnormalities in affective issues. It covers the appliance of imaging ideas to review key neurotransmitter structures for the tracking of therapy responses and the advance of latest remedies.

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SPECT functional brain imaging. Technical considerations. J Neuroimaging 1995; 5(suppl 1):S2-S13. Reba RC. PET and SPECT: opportunities and challenges for psychiatry. J Clin Psychiatry 1993; 54(suppl):26-32. Humphreys GW, Price CJ. Cognitive neuropsychology and functional brain imaging: implications for functional and anatomical models of cognition. Acta Psychol 2001; 107:119-153. Copyrighted Material 16 Sassi and Soares 23. Lewine JD, Orrison WW Jr. Clinical electroencephalography and event-related potentials.

Pharmacol Res 2001; 44(3):151-159. Kapur S. A new framework for investigating antipsychotic action in humans: lessons from PET imaging. Mol Psychiatry 1998; 3(2):135-140. Slifstein M, Laruelle M. Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers. Nuc Med BioI 2001; 28:595-608. Ichise M, Meyer JH, Yonekura Y. An introduction to PET and SPECT neuroreceptor quantification models. J Nucl Med 2001; 42:755-763. Devous MD. SPECT functional brain imaging.

Measurements of motor excitability, studies of the role of the prefrontal cortex and other connected regions in the regulation of mood, and studies of cognitive function in normal subjects and patients are examples of some of the applications. Further studies in basic animal research to understand the mechanism of action of TMS, patient studies with improved study designs and larger systematic investigations, and technical improvements will all help to expand research in this field and increase its clinical relevance.

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