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And Dedonder, R. (1974). Biochimie 56, 1481-1489. 98. Kunst, F . , Lepesant, J-A, and Dedonder, R. (1977). Biochimie 59, 287-292. 99. Laipis, J. , and Ganesan, Α. T. (1972). J. Biol. Chem. 247, 5 8 6 7 - 5 8 7 1 . 100. LeHegarat, J-C, and Anagnostopoulos, C. (1969). C. R. Acad. Sei. Paris 269, 2048-2050. 101. LeHegarat, J-C, and Anagnostopoulos, C. (1973). Eur. J. Biochem. 39, 5 2 5 - 5 3 9 . 102. , and Anagnostopoulos, C. (1969). Bull. Soc. Chim. Biol. 5 1 , 6 9 1 - 7 0 7 . 103. Lepesant, J-A, Kunst, F .

4 1 8 - 4 2 8 . , Amsterdam. 2. A d a m s , A . (1972). Mol. Gen. Genet. 118, 3 1 1 - 3 2 2 . 3. A d a m s , Α . , and Oishi, M. (1972). Mol. Gen. Genet. 118, 2 9 5 - 3 1 0 . 4. Aharonowitz, Y . , and R o n , Ε . Z. (1972). Mol. Gen. Genet. 119, 131-138. 5. Albertini, Α . M . , and Galizzi, A . (1975). J. Bacteriol. 124, 1 4 - 2 5 . 6. A n a g n o s t o p o u l o s , C , and Crawford, I. P. (1961). Proc. Nat. Acad. Sei. USA 47, 378-390. 28 DENNIS J. HENNER AND JAMES Α. HOCH 7. Anagnostopoulos, C , and Schneider-Champagne, Α.

W a k e (1972) visualized d i c h o t o m o u s replication after thymine starvation using autoradiography. H e o b s e r v e d a p r e d o m i n a n c e of structures that w e r e symmetric b u t , as he stated, t h e r e w e r e m a n y facets of the experiment that could h a v e possibly biased the results in favor of either a symmetric or an a s y m m e t r i c m o d e . K a u f m a n (1976) did find, h o w e v e r , that nalidixic acid t r e a t m e n t ind u c e d the a s y m m e t r i c m o d e of replication in B.

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